I’m William DePaolo, PhD

Immunologist & Gut Health Expert

Growing up in an Italian-American Family in Portland, Maine I spent a lot of time in the kitchen and at the beach. If I wasnt exploring tide pools and staring out at the waves, I was in my grandparents kitchen. As a scientist, I am still exploring habitats but instead of the tidal pool community, I study the community of bacteria residing in our gut. And nutrition plays a big role in shaping this community.

I’m a PhD immunologist and translational program leader with 15 plus years across academia and industry facing work, focused on turning fast moving science into decisions that hold up under pressure. I’ve led complex research portfolios, coordinated multi site clinical and preclinical efforts, managed external partners and CRO style workstreams, and built the infrastructure that makes teams faster without getting sloppier. I’m known for clarity. I don’t do hand waving, and I don’t let teams ship conclusions that the methods can’t support.

My work has spanned inflammation, metabolism, oncology, and microbiome-driven programs. Along the way, I’ve built and led cross discipline teams (biology, computational, clinical, and external collaborators), delivered congress ready scientific content, and translated technical findings into materials that executives, medical affairs, and commercial stakeholders can actually use.

Today, I consult with research teams, startups, and health focused organizations that need rigor and traction at the same time. That can include study design and endpoint strategy, microbiome QC and pipeline review, vendor and partner evaluation, results interpretation, and scientific storytelling that stays defensible. If you’re trying to move from “interesting signal” to “real world outcome,” I’m here to make the science tighter, the decisions cleaner, and the timeline shorter.

If you want a quick gut check on a study, a pipeline, or a microbiome product strategy, reach out.