PEER-REVIEWED PUBLICATIONS

1.Genomic and functional characterization of a mucosal symbiont involved in early-stage colorectal cancer.

Kordahi MC, Stanaway IB, Avril M, Chac D, Blanc MP, Ross B, Diener C, Jain S, McCleary P, Parker A, Friedman V, Huang J, Burke W, Gibbons SM, Willis AD, Darveau RP, Grady WM, Ko CW, DePaolo RW. Cell Host Microbe. 2021 Oct 13;29(10):1589-1598.e6. doi: 10.1016/j.chom.2021.08.013. Epub 2021 Sep 17. PMID: 34536346

2.Sample Preparation for Detection of Different Bacterial Strains by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight (MALDI-TOF) Mass Spectrometry.

Chac D, Kordahi M, Brettner L, DePaolo RW. Curr Protoc. 2021 Aug;1(8):e212. doi: 10.1002/cpz1.212. PMID: 34370396

3.Microbial single-cell RNA sequencing by split-pool barcoding.

Kuchina A, Brettner LM, Paleologu L, Roco CM, Rosenberg AB, Carignano A, Kibler R, Hirano M, DePaolo RW, Seelig G. Science. 2021 Feb 19;371(6531):eaba5257. doi: 10.1126/science.aba5257. Epub 2020 Dec 17. PMID: 33335020

4."Driver-passenger" bacteria and their metabolites in the pathogenesis of colorectal cancer.

Avril M, DePaolo RW. Gut Microbes. 2021 Jan-Dec;13(1):1941710. doi: 10.1080/19490976.2021.1941710. PMID: 34225577. Review.

5.Toll-like Receptor-6 Signaling Prevents Inflammation and Impacts Composition of the Microbiota During Inflammation-Induced Colorectal Cancer.

Kim JH, Kordahi MC, Chac D, DePaolo RW. Cancer Prev Res (Phila). 2020 Jan;13(1):25-40. doi: 10.1158/1940-6207.CAPR-19-0286. Epub 2019 Nov 26. PMID: 31771941

6.Commensal Bacteria Decontaminating Your Diet.

Kordahi MC, DePaolo RW. Cell Host Microbe. 2019 Oct 9;26(4):446-448. doi: 10.1016/j.chom.2019.09.013. PMID: 31600496

7.Infectious Scarring: Setting the Trigger for Intestinal Inflammation.

Johnson AMF, DePaolo RW. Cell Host Microbe. 2018 Feb 14;23(2):154-156. doi: 10.1016/j.chom.2018.01.017. PMID: 29447693

8.Innate Recognition of the Microbiota by TLR1 Promotes Epithelial Homeostasis and Prevents Chronic Inflammation.

Kamdar K, Johnson AMF, Chac D, Myers K, Kulur V, Truevillian K, DePaolo RW. J Immunol. 2018 Jul 1;201(1):230-242. doi: 10.4049/jimmunol.1701216. Epub 2018 May 23. PMID: 29794015

9.Predictive value of TLR7 polymorphism for cetuximab-based chemotherapy in patients with metastatic colorectal cancer.

Okazaki S, Stintzing S, Sunakawa Y, Cao S, Zhang W, Yang D, Ning Y, Matsusaka S, Berger MD, Miyamoto Y, Suenaga M, Schirripa M, West JD, Gopez R, Akihito T, Ichikawa W, Heinemann V, DePaolo RW, Lenz HJ. Int J Cancer. 2017 Sep 15;141(6):1222-1230. doi: 10.1002/ijc.30810. PMID: 28569041

10. Retinoic acid can exacerbate T cell intrinsic TLR2 activation to promote tolerance.

Nguyen V, Pearson K, Kim JH, Kamdar K, DePaolo RW. PLoS One. 2015 Mar 31;10(3):e0118875. doi: 10.1371/journal.pone.0118875. eCollection 2015.

PMID: 25826367

11. Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease.

Kamdar K, Khakpour S, Chen J, Leone V, Brulc J, Mangatu T, Antonopoulos DA, Chang EB, Kahn SA, Kirschner BS, Young G, DePaolo RW.

Cell Host Microbe. 2016 Jan 13;19(1):21-31. doi: 10.1016/j.chom.2015.12.006. PMID: 26764594.

12.Window-of-opportunity: neonatal gut microbiota and atopy.

Johnson AMF, DePaolo RW. Hepatobiliary Surg Nutr. 2017 Jun;6(3):190-192. doi: 10.21037/hbsn.2017.03.05. PMID: 28653002

13. Clinical Significance of TLR1 I602S Polymorphism for Patients with Metastatic Colorectal Cancer Treated with FOLFIRI plus Bevacizumab.

Okazaki S, Loupakis F, Stintzing S, Cao S, Zhang W, Yang D, Ning Y, Sunakawa Y, Stremitzer S, Matsusaka S, Berger MD, Parekh A, West JD, Miyamoto Y, Suenaga M, Schirripa M, Cremolini C, Falcone A, Heinemann V, DePaolo RW, Lenz HJ. Mol Cancer Ther. 2016 Jul;15(7):1740-5. doi: 10.1158/1535-7163.MCT-15-0931. Epub 2016 May 11. PMID: 27196764

14. TLR1-induced chemokine production is critical for mucosal immunity against Yersinia enterocolitica.

Sugiura Y, Kamdar K, Khakpour S, Young G, Karpus WJ, DePaolo RW. Mucosal Immunol. 2013 Nov;6(6):1101-9. doi: 10.1038/mi.2013.5. Epub 2013 Feb 27. PMID: 23443468

15.Genetic variants associated with Crohn's disease.

Michail S, Bultron G, DePaolo RW. Appl Clin Genet. 2013 Jul 16;6:25-32. doi: 10.2147/TACG.S33966. Print 2013. PMID: 23935379

16. Toll-like receptor signaling and regulation of intestinal immunity.

Kamdar K, Nguyen V, DePaolo RW. Virulence. 2013 Apr 1;4(3):207-12. doi: 10.4161/viru.23354. PMID: 23334153 . Review.

17. A specific role for TLR1 in protective T(H)17 immunity during mucosal infection.

DePaolo RW, Kamdar K, Khakpour S, Sugiura Y, Wang W, Jabri B. J Exp Med. 2012 Jul 30;209(8):1437-44. doi: 10.1084/jem.20112339. PMID: 22778390

18.Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens.

DePaolo RW, Abadie V, Tang F, Fehlner-Peach H, Hall JA, Wang W, Marietta EV, Kasarda DD, Waldmann TA, Murray JA, Semrad C, Kupfer SS, Belkaid Y, Guandalini S, Jabri B. Nature. 2011 Mar 10;471(7337):220-4. doi: 10.1038/nature09849. PMID: 21307853

19.Mice deficient for CCR6 fail to control chronic experimental autoimmune encephalomyelitis.

Elhofy A, DePaolo RW, Lira SA, Lukacs NW, Karpus WJ. J Neuroimmunol. 2009 Aug 18;213(1-2):91-9. doi: 10.1016/j.jneuroim.2009.05.011. PMID: 19535153

20.Toll-like receptor 6 drives differentiation of tolerogenic dendritic cells and contributes to LcrV-mediated plague pathogenesis.

DePaolo RW, Tang F, Kim I, Han M, Levin N, Ciletti N, Lin A, Anderson D, Schneewind O, Jabri B. Cell Host Microbe. 2008 Oct 16;4(4):350-61. doi: 10.1016/j.chom.2008.09.004. PMID: 18854239

21.The chemokine CCL2 is required for control of murine gastric Salmonella enterica infection.

DePaolo RW, Lathan R, Rollins BJ, Karpus WJ. Infect Immun. 2005 Oct;73(10):6514-22. doi: 10.1128/IAI.73.10.6514-6522.2005. PMID: 16177325

22. Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV.

DeBord KL, Anderson DM, Marketon MM, Overheim KA, DePaolo RW, Ciletti NA, Jabri B, Schneewind O. Infect Immun. 2006 Aug;74(8):4910-4. doi: 10.1128/IAI.01860-05. PMID: 16861680

23.Plague bacteria target immune cells during infection.

Marketon MM, DePaolo RW, DeBord KL, Jabri B, Schneewind O. Science. 2005 Sep 9;309(5741):1739-41. doi: 10.1126/science.1114580. Epub 2005 Jul 28. PMID: 16051750. , both authors contributed equally to this work.

24. LcrV plague vaccine with altered immunomodulatory properties.

Overheim KA, DePaolo RW, Debord KL, Morrin EM, Anderson DM, Green NM, Brubaker RR, Jabri B, Schneewind O. Infect Immun. 2005 Aug;73(8):5152-9. doi: 10.1128/IAI.73.8.5152-5159.2005. PMID: 16041032

25. CCR5 regulates high dose oral tolerance by modulating CC chemokine ligand 2 levels in the GALT.

DePaolo RW, Lathan R, Karpus WJ. J Immunol. 2004 Jul 1;173(1):314-20. doi: 10.4049/jimmunol.173.1.314. PMID: 15210789

26.CC chemokine ligand 2 and its receptor regulate mucosal production of IL-12 and TGF-beta in high dose oral tolerance.

DePaolo RW, Rollins BJ, Kuziel W, Karpus WJ. J Immunol. 2003 Oct 1;171(7):3560-7. doi: 10.4049/jimmunol.171.7.3560. PMID: 14500652